Gives an overview of the achievements in the field of skin gene therapy focusing on basic research and initial preclinical applications. This work describes techniques of generating epidermal equivalents from hair follicle cells, the reaction of keratinocytes to exogenous DNA, and the genetic engineering of skin to be used as a bioreactor.
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Complete description
In recent years the skin has become an important target organ of gene technology and gene therapy. Its easy accessibility, well-established culture conditions and grafting techniques, as well as its function as an immune organ make it a promising candidate for the development of innovative treatment strategies. This special issue of "Cells Tissues Organs" gives an overview of the latest achievements in the field of skin gene therapy focusing on basic research and initial preclinical applications. It describes novel techniques of generating epidermal equivalents from hair follicle cells, the reaction of keratinocytes to exogenous DNA, and the genetic engineering of skin to be used as a bioreactor or a 'metabolic sink' in the treatment of metabolic disorders. Further potential applications of skin gene therapy include the treatment of chronic wounds, hypertrophic scars, keloids, and cancer, as well as its role in soft tissue reconstruction.
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Summary
Gene Technology and Gene Therapy in Dermatology
Use of epidermal equivalents generated from follicular outer root sheath cells in vitro and for autologous grafting of chronic wounds, A. Limat, T. Hunziker; reaction of keratinocytes to exogenous DNA, A. Mirmohammadsadegh, J. Maschke, E. Basner-Tschakarjan, A. Bar, U.R. Hengge; skin genetically engineered as a bioreactor or a "metabolic sink", R. Christensen, U.B. Jensen, T.G. Jensen; treatment of chronic wounds - state of the art and future concepts, S.A. Eming, H. Smola. T. Krieg; gene therapy in soft tissue reconstruction, D. Hoeller, N. Petrie, F. Yao, E. Eriksson; apoptotic genes in cancer therapy, S. Fruehauf, M.R. Veldwijk, S. Berlinghof, et al.
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